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Use of DPP4 inhibitors in Italy does not correlate with diabetes prevalence among COVID-19 deaths.
Strollo, Rocky; Maddaloni, Ernesto; Dauriz, Marco; Pedone, Claudio; Buzzetti, Raffaella; Pozzilli, Paolo.
Diabetes Res Clin Pract ; 171: 108444, 2021 Jan.
Article in English | MEDLINE | ID: covidwho-764474

ABSTRACT

In a nationwide study of 3818 charts from patients with fatal COVID-19, we found that geographical differences in Dipeptidyl peptidase 4 (DPP4) inhibitors use did not correlate with diabetes prevalence among COVID-19 deaths, thus not supporting the hypothesis of a clinically relevant involvement of DPP4 inhibition in COVID-19 development and progression.


Subject(s)
COVID-19/mortality , Diabetes Mellitus/drug therapy , Dipeptidyl Peptidase 4/chemistry , Dipeptidyl-Peptidase IV Inhibitors/therapeutic use , SARS-CoV-2/drug effects , COVID-19/transmission , COVID-19/virology , Diabetes Mellitus/epidemiology , Diabetes Mellitus/virology , Humans , Italy/epidemiology , Prevalence , Prognosis , SARS-CoV-2/isolation & purification , Survival Rate
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